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KMID : 0379520130290020099
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한국독성학회지
2013 Volume.29 No. 2 p.99 ~ p.106
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In Vitro Evaluation of Antimicrobial Activity of Lactic Acid Bacteria against Clostridium difficile
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Lee Joong-Su
Seo Jae-Gu
Chung Myung-Jun
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Abstract
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lostridium difficile infection (CDI) has become a significant threat to public health. Although broad-spectrum antibiotic therapy is the primary treatment option for CDI, its use has evident limitations. Probiotics have been proved to be effective in the treatment of CDI and are a promising therapeutic option for CDI. In this study, 4 strains of lactic acid bacteria (LAB), namely, Lactobacillus rhamnosus (LR5), Lactococcuslactis (SL3), Bifidobacterium breve (BR3), and Bifidobacterium lactis (BL3) were evaluated for their anti-C. difficile activity. Co-culture incubation of C. difficile (106 and 1010 CFU/ml) with each strain of LAB indicated that SL3 possessed the highest antimicrobial activity over a 24-hr period. The cell-free supernatants of the 4 LAB strains exhibited MIC50 values between 0.424 mg/ml (SL3) and 1.318 (BR3) mg/ml. These results may provide a basis for alternative therapies for the treatment of C. difficile-associated gut disorders.
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KEYWORD
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Clostridium difficile infection, lactic acid bacteria, antimicrobial activity, cell-free supernatant
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